Positives

• Patients enrolled in the Mayo Clinic post-COVID nVNS study reported reductions in headache, brain fog, fatigue, and gastric distress after self-administered handheld neck stimulation Biospace.
  
  
• Across VNS treatment groups, patients reported reduction in fatigue and dyspnea after 12 weeks of handheld stimulation Frontiers.
  
  

Negatives

• Some patients in the post-COVID handheld nVNS cohort reported no meaningful symptom change at study endpoints, with response highly individual Health Rising.
  
  
• Patients describe the requirement to deliver multiple 2-minute neck stimulations daily as time-consuming and easy to forget when fatigued Health Rising.
  
  

Hurdles & Side Effects

• Prescription-only handheld nVNS devices are typically several hundred dollars per month with rolling refill cards, and Long COVID is not an approved indication so patients pay out of pocket Biospace.
  
  
• Patients must obtain an Rx, often through migraine or headache specialists, since neurologists rarely prescribe nVNS for post-COVID indications NIH.