Positives

• A long-hauler with severe ME/CFS-type symptoms and consistently low folate levels started methylfolate supplementation and reported no adverse effects, noting that their low B6 conversion issues and menstrual symptom worsening both suggested folate metabolism was disrupted by COVID Reddit.
  
  
• A patient who had been long-hauling for 14 months reported near-complete recovery after identifying magnesium deficiency as the root cause, supported by methyl B vitamins including folate for proper magnesium utilization Reddit.
  
  

Negatives

• A patient with SIBO and slow motility (a post-infectious condition) took a single 1.5mg dose of methylfolate and experienced the worst migraine of their life at 4am, requiring two antihistamines, with recurring behind-the-eye migraines persisting for days Reddit.
  
  

Hurdles & Side Effects

• Research shared in the community showed that exercise worsens brain metabolism in ME/CFS partly by depleting folate metabolites, suggesting that folate supplementation may be particularly important for patients experiencing post-exertional malaise Reddit.