Positives

• CIRS patients with elevated C3a using high-dose fluvastatin (typically 80 mg) reported normalization of C3a and reduction of inflammation-driven symptoms Surviving Mold.
  
  
• Pretreating with 150 mg of CoQ10 for ten days helped patients tolerate the high statin dose with fewer muscle complaints Surviving Mold.
  
  

Negatives

• Patients on high-dose statins frequently report muscle pain, weakness, and fatigue that can be hard to separate from baseline CIRS symptoms Drugs.com.
  
  
• Some patients had to stop because of GI upset, headache, and rising liver enzymes on the 80 mg/day dose Surviving Mold.
  
  

Hurdles & Side Effects

• Insurers often balk at covering an 80 mg fluvastatin prescription for a non-cardiac indication, forcing patients to pay cash or appeal Surviving Mold.
  
  
• The protocol requires patients to confirm MARCoNS has been cleared first, since starting a statin earlier can blunt the C3a response and confuse interpretation Surviving Mold.