Positives

• In a Nature Medicine RCT, ~45% of patients using the Flow headset achieved depression remission vs ~22% of sham Nature Medicine.
  
  
• An NHS crisis service reported up to a 75% drop in suicidal ideation and significant mood improvement within 2-3 weeks of use BrainFacts.
  
  

Negatives

• Patients reported scalp tingling, headache, and skin redness under the electrodes during 2.0 mA sessions FDA.
  
  
• A patient noted no Long COVID-specific RCTs yet exist, so fatigue benefit is extrapolated from depression data PMC.
  
  

Hurdles & Side Effects

• Patients face a sizable upfront cost plus subscription, with limited US insurance coverage Taylor & Francis.
  
  
• A patient noted 5 sessions per week for 10 weeks demand consistent compliance that is hard during PEM Nature Medicine.