Positives

• A patient with post-COVID secondary hypogonadism saw LH, FSH and total testosterone normalize on enclomiphene without crashing semen parameters PMC.
  
  
• Compared with TRT, fewer reports of mood swings, libido drop or low energy on enclomiphene in pooled hypogonadism cohorts PMC.
  
  

Negatives

• A long-COVID review noted testosterone restoration improved hypogonadism labs but did not clearly lift fatigue or quality-of-life scores tied to LC itself PMC.
  
  
• Patients reported visual disturbances, mood lability and headache during titration RxList.
  
  

Hurdles & Side Effects

• Enclomiphene is not FDA-approved as a standalone drug, leaving patients dependent on compounding pharmacies HealthOn.
  
  
• Only works for secondary (HPG-axis) hypogonadism, so primary testicular failure patients see no benefit Translational Andrology.