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Reviews

Summary

Positives

  • A patient at roughly 20% baseline for 3 years started 30mg duloxetine and after 6 weeks reached about 70%—cleaning the garage and walking 6,000–7,000+ steps daily Reddit.

  • A patient reported that Cymbalta eliminated a 6-month-long post-COVID headache Reddit.

Negatives

  • A patient reported that duloxetine made symptoms worse, especially heart rate Reddit.

Hurdles & Side Effects

  • Withdrawal from duloxetine is widely feared; multiple patients hesitate to start it due to reported difficulty discontinuing, and drug interactions (e.g., with Flonase and curcumin) triggered anxiety, insomnia, and racing heart in one patient Reddit.

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posted Anonymously

@anonymous

Side effects included dry mouth, etc, terrible to withdraw from

Chronic Illnesses: Long COVID
Symptoms Treated: All - Worse short time
Side Effects Experienced: Withdrawl Dry Mouth

don’t use this if you have dry mouth issues otherwise, or brain fog

Details

  • Source Neurologist
  • Last used 6-12 mo ago
  • Times used 11-50 times
  • Insurance covered Yes
  • Cost per month $1-$99