Positives

• One reviewer reported minimal side effects and a meaningful drop in blood sugar within weeks of starting weekly Trulicity injections Drugs.com.
  
  
• A patient who switched off semaglutide during a shortage said the prefilled Trulicity pen was simple to use and kept appetite controlled between weekly doses Drugs.com.
  
  

Negatives

• Up to 21% of patients reported nausea, with diarrhea in 14% and vomiting in 12%, especially in the first weeks after each dose escalation Drugs.com.
  
  
• A patient described severe abdominal pain and persistent vomiting in the days after injection, leading to early discontinuation Drugs.com.
  
  

Hurdles & Side Effects

• With an average rating of 5.3 of 10 across 980 reviews, patients found tolerability unpredictable and many had to titrate slowly to stay on the drug Drugs.com.
  
  
• A reviewer noted that fatigue from Trulicity stacked with existing post-viral exhaustion, making it hard to tell which symptoms were the drug and which were the illness WebMD.