Positives

• Dexedrine for the last \~4 years has been quite helpful for me on bad days, or days when I needed to get a lot of things done Reddit.
• When taking Dexedrine with a stable dose of LDA, they felt a slight energy bump, but its effectiveness is drastically reduced Reddit.

Negatives

• No published Long COVID trials show benefit from dextroamphetamine, and patients on chronic high doses report a marked crash phase with depression, anxiety, and fatigue lasting up to 3 to 4 weeks after stopping NIH StatPearls.
• Reported side effects at therapeutic doses include increased heart rate, anxiety, irritability, insomnia, and bruxism, all of which can worsen POTS and dysautonomia overlap Cleveland Clinic.
• Schedule II status means monthly office visits, no automatic refills, and ongoing pharmacy supply problems MedlinePlus.

Hurdles & Side Effects

• One user noted that Dexedrine previously gave a traditional stimulant feeling, but when taken with a stable dose of LDA, they felt a slight energy bump, but its effectiveness is drastically reduced Reddit.