Positives

• A patient with Barrett's esophagus who had failed Tums, Nexium, and Prilosec reported zero heartburn and zero reflux on Dexilant, with a follow-up endoscopy showing incredible esophagus healing Drugs.com.
  
  
• Patients valued that Dexilant's dual-release capsule could be taken any time of day without regard to food, simplifying dosing for those with MCAS-related meal triggers Drugs.com.
  
  

Negatives

• One reviewer became extremely anxious and depressed after a few weeks on Dexilant, with crying spells and panic attacks that resolved off the drug Drugs.com.
  
  
• Several patients reported gas and diarrhea on Dexilant, with one finding kefir helped offset the GI side effects Drugs.com.
  
  

Hurdles & Side Effects

• Patients consistently flagged Dexilant as very expensive and requiring insurance prior authorization, an obstacle for those whose insurer prefers generic PPIs Drugs.com.
  
  
• Long-term users risk reduced vitamin B12 absorption and low magnesium, with magnesium depletion potentially triggering seizures or arrhythmias after three or more years WebMD.