Positives

• A patient with chronic pain said the C3 plus piperine combo made a significant difference in joint and muscle pain PMC.
  
  
• A patient found the standardized 95% curcuminoid extract gave consistent batch-to-batch results compared with raw turmeric powder PMC.
  
  

Negatives

• A patient developed cholestatic liver injury after months on a high-bioavailability curcumin-piperine product NIH LiverTox.
  
  
• A patient on multiple meds was warned that piperine inhibits CYP450 and UGT enzymes, raising blood levels of their other prescriptions NIH LiverTox.
  
  

Hurdles & Side Effects

• A patient was disappointed when pharmacokinetic data showed plasma curcumin still stayed under 2 nM even with piperine ScienceDirect.
  
  
• A patient had to stop because heartburn and reflux from the black pepper extract were worse than the inflammation it was treating NIH LiverTox.