Positives

• A patient with persistent Lyme co-infections reported less head pressure, less dizziness, and more energy within a week of slowly titrating up cryptolepis tincture LymeDisease.org.
  
  
• A patient who had failed multiple antibiotic courses said cryptolepis produced a noticeable shift in joint pain, fatigue, and brain fog within a relatively short time Frontiers.
  
  

Negatives

• Patients consistently described cryptolepis as one of the worst-tasting tinctures in the protocol, bad enough that some had to quit despite tolerating it physically LymeDisease.org.
  
  

Hurdles & Side Effects

• Patients had to start at very low doses and titrate up slowly to avoid Herxheimer reactions, a process that stretched on for weeks before reaching a therapeutic level LymeDisease.org.