Positives

• One individual dealing with post-COVID hormone and gut issues noted that cholestyramine helped manage their loose stool caused by bile, and speculated it might also be “helping bind other crap” in their gut Reddit.
  
  

Negatives

• One long COVID patient reported that using cholestyramine as a binder led to constipation, necessitating the use of coffee enemas, which they described as “not pretty” Reddit.
  
  
• A patient with severe medicine sensitivities found that even small amounts of cholestyramine caused a “crash + baseline worsens,” indicating it may not be suitable for everyone Reddit.
  
  

Hurdles & Side Effects

• One patient mentioned that taking cholestyramine requires a prescription and can be challenging, as it may initially exacerbate symptoms for a few days while “flushing things out” Reddit.