Positives

• A patient with autoinflammatory disease reported significant improvement in physical and mental quality of life scores by day 8 after the first injection, including reductions in fever, joint pain, and fatigue Rheumatology.org.
  
  
• Long-term users reported sustained well-being on every-8-week dosing, which was much less burdensome than the daily injections required by anakinra PMC.
  
  

Negatives

• A patient described painful redness and swelling at the injection site occurring in roughly one in six injections, occasionally severe enough to warrant ice and analgesics Drugs.com.
  
  
• Several users reported recurrent upper respiratory infections and abdominal symptoms that they tied to the medication Drugs.com.
  
  

Hurdles & Side Effects

• A patient seeking this IL-1β blocker for post-viral fatigue after failing anakinra found the drug's listed price among the highest in rheumatology, with prior authorization repeatedly denied without an autoinflammatory syndrome diagnosis Drugs.com.
  
  
• A patient was required to complete TB screening and confirm immunization status before her first dose, delaying treatment by several weeks FDA.