Positives

• A patient started Wellbutrin after months of severe LC depression and after only 3 days their brain was more alert; after 1 week they woke up happy and could focus on small tasks again Reddit.
  
  
• A long-hauler with brain fog since August 2023 started Wellbutrin and by day 4 saw “huge improvement” in cognitive functioning, noting they had not had 4 good days in a row in almost a year Reddit.
  
  

Negatives

• A patient on 300mg XL for 4 months reported daily headaches, mood swings, worsened working memory, and negligible fatigue improvement Reddit.
  
  
• A patient reported bupropion made their LC fatigue worse even though it helped depression, creating an impossible trade-off Reddit.
  
  

Hurdles & Side Effects

• A patient who increased from 150mg to 300mg developed severe insomnia leading to a crash, and suspected the medication masked energy resources contributing to worsening cycles Reddit.
  
  
• Bupropion increases blood levels of antihistamines, potentially complicating the popular H1/H2 antihistamine protocol many LC patients use Reddit.