Positives

• A study of inhaled DMT found that participants whose well-being improved after the experience showed sympathetic and parasympathetic co-activation, suggesting an autonomic reset mechanism relevant to long-haulers SAGE Journal of Psychopharmacology.
  
  
• A 2024 review noted only one published case series and one case report, but both described symptom relief in Long COVID patients after serotonergic psychedelic sessions ScienceDirect review.
  
  

Negatives

• A systematic review of ayahuasca and DMT adverse events catalogued vomiting, transient psychosis, cardiovascular spikes, and rare deaths during ceremonies SAGE Adverse Events Review.
  
  

Hurdles & Side Effects

• The MAOI in the ayahuasca brew interacts dangerously with SSRIs, tyramine foods, and many supplements long-haulers already take, requiring a long taper window before sessions PMC pharmacology review.