Positives

• A 22-year-old male with SOB, brain fog, headaches, fatigue, and POTS tried 325mg aspirin after 81mg did nothing, and on the first day could breathe normally with fatigue and headaches dramatically reduced Reddit.
  
  
• A long-hauler with crippling fatigue started 650mg aspirin every four hours and within 12 hours felt their body “come alive” — walking dogs, doing laundry, and taking stairs again Reddit.
  
  

Negatives

• A patient who started 80mg aspirin felt way more tired, as if exhaustion from their initial months of illness had returned Reddit.
  
  
• A patient noticed baby aspirin reduced symptoms but increased their tinnitus, feeling stuck between symptom relief and worsening hearing issues Reddit.
  
  

Hurdles & Side Effects

• A top commenter strongly warned against high-dose aspirin due to risks of GI bleeding, severe kidney and liver damage, increased stroke risk, and aspirin resistance causing rebound clotting Reddit.
  
  
• A commenter reported that aspirin can aggravate mast cells, noting that aspirin combined with other medications led to terrifying mast cell attacks Reddit.