Positives

• A patient with ME/CFS reported significant health improvements, including reduced dizziness and hypersomnia, after incorporating ashwagandha into their regimen, moving from a health rating of 2-3/10 to 8/10 Health Rising.
  
  
• One patient with post-COVID symptoms noted that ashwagandha, as part of a combination regimen, “helped a lot” with their insomnia, although the effect diminished over time Mayo Clinic Connect.
  
  
• One person found that ashwagandha contributed to a reduction in brain fog and improved their overall functionality and sense of normalcy Mayo Clinic Connect.
  
  

Negatives

• One person experienced heart palpitations for a week after using ashwagandha in a cream form, even with a small amount Health Rising.
  
  

Hurdles & Side Effects

• KSM-66 is a root-only full-spectrum extract standardized to 5% withanolides, while Sensoril uses root and leaf with higher withanolide concentration; the two are not interchangeable in clinical doses HL Benefits.
• Denmark banned ashwagandha supplements in 2023 and France’s ANSES followed in 2024 over thyroid and hormonal concerns; one Drugs.com reviewer described palpitations, headache and stomach upset within a week, and patients on levothyroxine are urged to recheck TSH Drugs.com.