Positives

• Patients note that Kineret injections were well-tolerated with a lack of side effects compared to other immune-modulating medications Phoenix Rising.
• One patient reported using Kineret specifically for vaccine-induced myocarditis with positive engagement Phoenix Rising.

Negatives

• A Drugs.com reviewer with chronic inflammatory arthritis stopped Kineret because daily injection-site burning, swelling, and welts became unbearable; another wrote that the daily shot routine took a psychological toll on top of fatigue that did not lift Drugs.com.
• ME/CFS patients on daily Kineret commonly report the burden of shots without proportionate fatigue relief; even those completing months of treatment most often see no meaningful change in fatigue scores ME Association.

Hurdles & Side Effects

• Up to 70% of Kineret users experience injection-site burning, redness, and swelling, with reactions usually appearing within the first weeks and lasting two to four weeks; one Drugs.com reviewer warned the burn “is not in the literature” and described needing to warm syringes to body temperature first Drugs.com.
• Prescription Hope lists Kineret’s cash price near $204 per pre-filled syringe, putting a 100 mg/day course around $3,800 per month, and the drug is rheumatology-only with FDA approval limited to RA, NOMID and DIRA, so any Long COVID use is off-label and rarely covered.