Positives

• A patient with ME/CFS noted that amantadine improved their overall energy levels, making daily activities with their toddler more manageable, although they initially experienced some jitteriness at higher doses Health Rising.
  
  
• One person with a chronic condition and CatEye Syndrome found amantadine helpful during symptom flares and effective against influenza A, experiencing only brief illness with influenza B Health Rising.
  
  
• A patient reported stability while on amantadine, with their neurologist noting that speech pathology was the most effective intervention alongside the medication Mayo Clinic Connect.
  
  
• Another long COVID sufferer experiencing brain fog mentioned gradual improvement over two months of using amantadine, although they expressed concern about potential melanoma risks Mayo Clinic Connect.
  
  

Negatives

• A patient with ME/CFS and POTS reported that amantadine was “no help at all” and instead increased adrenaline, worsening their symptoms Health Rising.
  
  
• One person recalled that amantadine did nothing for their ME/CFS symptoms, echoing similar experiences from others who found it ineffective Health Rising.
  
  
• One patient shared that amantadine did not improve their fatigue or post-exertional malaise, leading them to discontinue use after a few months Health Rising.
  
  

Hurdles & Side Effects

• Initial side effects such as jitteriness and double vision were reported, but these often resolved with dose adjustments or over time Health Rising.
  
  
• Concerns about potential side effects, including melanoma risk, were noted by some patients, impacting their comfort with long-term use Mayo Clinic Connect.