Positives

• Patients in a UK primary-care interview study described meaningful anxiety relief and said they would recommend the device to others F1000Research.
  
  
• A meta-analysis found patients had significant anxiety reduction with a large treatment effect compared to controls PMC.
  
  

Negatives

• Patients in a randomized depression trial saw no significant benefit over sham at the primary endpoint PubMed.
  
  
• A patient reported scalp tingling, mild dizziness, and skin irritation under the ear-clip electrodes NCBI Bookshelf.
  
  

Hurdles & Side Effects

• Patients face high device cost (~$800) and limited insurance coverage outside the VA system Frontiers.
  
  
• A patient noted daily 20-60 minute sessions are required for weeks before judging response F1000Research.