Positives

• Long-term safety data show daily use of 1,335-3,560 mg/day of agmatine sulfate over years has been well tolerated without serious adverse effects in published case series PMC.
  
  

Negatives

• Agmatine has not been tested specifically in Long COVID or ME/CFS trials; the case for use rests on extrapolation from small fiber neuropathy and sciatica data, and benefits in those studies were modest in absolute terms Scripps.
  
  

Hurdles & Side Effects

• Long-term safety data in pregnancy and lactation are not established, and agmatine theoretically interacts with imidazoline-receptor-acting drugs (clonidine, guanfacine), MAOIs, and some opioids — consultation before chronic use is reasonable Genetic Lifehacks.