Positives

• A patient with ME/CFS found that taking acetyl-L-carnitine at low doses in the morning allowed them to exceed their “normal energy envelope” without significant post-exertional malaise, and they experienced minimal side effects Health Rising.
  
  

Negatives

• One patient noted that acetyl-L-carnitine did not improve their fatigue despite reaching normal carnitine levels Health Rising.
  
  
• In another report, a patient experienced only a “marginal” mood improvement for one day before returning to their baseline, leading them to discontinue acetyl-L-carnitine Health Rising.
  
  

Hurdles & Side Effects

• A patient reported severe insomnia and mood disturbances while taking acetyl-L-carnitine, which resolved after discontinuation of the supplement Health Rising.
  
  
• In another report, a patient had to stop using acetyl-L-carnitine due to a “fishy” odor in their urine and body secretions, which was intolerable Health Rising.