Positives

• Patients in an open-label anxiety trial showed significant CGI-S and HARS improvement over baseline on acamprosate PMC.
  
  
• A reviewer reported feeling completely different after a couple of weeks, with racing thoughts and irritability gone where antidepressants had failed Drugs.com.
  
  

Negatives

• Some patients reported worsening anxiety rather than relief during early dosing Drugs.com.
  
  
• Diarrhea and gastrointestinal upset led several users to discontinue before the cumulative effect set in AskaPatient.
  
  

Hurdles & Side Effects

• The three-times-daily dosing schedule made adherence difficult for patients juggling other long-COVID medications Cleveland Clinic.
  
  
• Off-label use for brain fog or anxiety often requires patients to find a clinician willing to prescribe outside the alcohol-use indication Cleveland Clinic.