Positives

• One ME/CFS patient described 5-MeO-DMT/Bufo as part of a dramatic shift out of a severe baseline, alongside other interventions such as metformin. Reddit.

Negatives

• One patient explicitly warned that 5-MeO-DMT can be dangerous or life-threatening if used improperly, which makes it very different from ordinary supplement self-experiments. Reddit.

Hurdles & Side Effects

• Practical barriers include legality, screening, setting, supervision, psychiatric risk, and aftercare; this is a high-risk psychedelic experience, not an ordinary at-home supplement trial. Reddit.